Yellow fever is a serious mosquito-borne virus travelers should be aware of when visiting endemic regions. It’s most prevalent in Africa, Central/South America, and the Caribbean. Symptoms range from mild fever to severe organ failure and jaundice. There is no specific treatment; prevention is key. A yellow fever vaccine is highly effective and often required for entry into endemic countries. Travelers unable to get vaccinated should carefully assess the risks and consider avoiding high-risk areas. When people travel, they often wonder if there are diseases that they need to be worried about. After all, viruses, bacteria, and parasites can be different around the world. Yellow fever is a condition that many people have heard of and wonder about when they travel.